Introduction: The level of involvement in economic activity of people with disabilities is influenced by various demographic factors. The objective of the work was an evaluation of the professional activities of persons with physical disabilities who were residents of the Lublin Province taking into account social and demographic conditions. Material and Methods: The survey was carried out in the period from May to October 2014 on a group of 233 persons with physical disabilities, residents of Lublin Province. The research tool was a questionnaire prepared by the author of the paper Results: The research results show that 51.07% (n=119) of the respondents declared that they were professionally active, and the social and demographic characteristics influencing their professional activity were age, place of residence, education, marital status, and level of disability (p<0.05). Conclusions: The most-significant determinants of PA in persons with disabilities are working age, living in a city, higher and secondary education, marital status, and a low or moderate level of disability.